prikaz prve stranice dokumenta Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
Embargo period 2021-10-18
doctoral thesis
Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
Split: University of Split, University of Split, Faculty of science, 2019. urn:nbn:hr:166:811997
Musa, Marina
University of Split
University of Split, Faculty of science
Department of Physics

Cite this document

Musa, M. (2019). Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans (Doctoral thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:811997

Musa, Marina. "Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans." Doctoral thesis, University of Split, University of Split, Faculty of science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:811997

Musa, Marina. "Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans." Doctoral thesis, University of Split, University of Split, Faculty of science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:811997

Musa, M. (2019). 'Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans', Doctoral thesis, University of Split, University of Split, Faculty of science, accessed 21 January 2021, https://urn.nsk.hr/urn:nbn:hr:166:811997

Musa M. Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans [Doctoral thesis]. Split: University of Split, University of Split, Faculty of science; 2019 [cited 2021 January 21] Available at: https://urn.nsk.hr/urn:nbn:hr:166:811997

M. Musa, "Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans", Doctoral thesis, University of Split, University of Split, Faculty of science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:811997

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Metadata
TitleMechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
Title (croatian)Mehanizmi produljenja života uslijed toplinskog šoka u Saccharomyces cerevisiae i Caenorhabditis elegans
AuthorMarina Musa
MentorAnita Kriško (mentor)
MentorMiroslav Radman (komentor)
Committee memberSandra Sobočanec (predsjednik povjerenstva)
Committee memberKatarina Vukojević (član povjerenstva)
Committee memberIrena Drmić-Hofman (član povjerenstva)
GranterUniversity of Split
University of Split, Faculty of science
(Department of Physics)
Split
Defense date and country2019-10-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Interdisciplinary Natural Sciences
Universal decimal classification
(UDC)		577
NATURAL SCIENCES
Biochemistry. Molecular biology. Biophysics
Abstract
Aging is a process almost all known organisms undergo and it is accompanied by a general loss of function of all important physiological processes, including reduced resistance to cellular stress. While different stresses such as heat or oxidative stress are generally detrimental to the cell and the organism, if they are short and mild enough, they can benefit the organism and confer increased stress resistance later in life and prolong lifespan. This phenomenon is known as hormesis. By studying and comparing the response of the cell to heat stress in S. cerevisiae and C. elegans, we wanted to better understand what is necessary for the stress to produce a hormetic effect. Research into the molecular mechanisms of hormesis can give us a better picture of the processes required for the maintenance of stress resistance in cells, how it can be preserved or restored in aging cells, and its effects in lifespan.
Abstract (croatian)
Starenje je proces koji se događa u skoro svim poznatim organizmima, a prati ga opći gubitak funkcije svih značajnih fizioloških procesa, uključujući otpornost na stanični stres. Dok različiti stresori poput visoke temperature ili oxidativnog stresa su generalno pogubni za stanicu i organizam, ako je stres dovoljno kratak i blag, može imati pozitivan utjecaj na organizam, učiniti ga otpornijim na stres kasnije u životu, te produžiti životni vijek. Ovaj fenomen se naziva hormeza. Istražujući i uspoređujući stanični odgovor na toplinski stres u S. cerevisiae i C. elegans, željeli smo bolje razumjeti što je potrebno da stres proizvede hormetski efekt. Istraživanje molekularnih mehanizama hormeze nam može dati bolji uvid u procese koji su potrebni da bi stanica održala otpornost na stres, kako se otpornost na stres može održati ili čak povratiti u starijim stanicama, te njen utjecaj na životni vijek.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:811997
Study programmeTitle: Postgraduate University Study of Biophysics
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
Extent110 str. ; 30 cm
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2021-10-18
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
RepositoryRepository of Faculty of Science
Created on2019-11-04 12:57:09

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