Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans

Musa, Marina

prikaz prve stranice dokumenta Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans

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doctoral thesis

Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans

Split: University of Split, University of Split, Faculty of science, 2019. urn:nbn:hr:166:811997

Musa, Marina

University of Split
University of Split, Faculty of science
Department of Physics

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APA 6th Edition

Musa, M. (2019). Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans (Doctoral thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:811997

MLA 8th Edition

Musa, Marina. "Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans." Doctoral thesis, University of Split, University of Split, Faculty of science, 2019. https://urn.nsk.hr/urn:nbn:hr:166:811997

Chicago 17th Edition

Harvard

Musa, M. (2019). 'Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans', Doctoral thesis, University of Split, University of Split, Faculty of science, accessed 09 February 2023, https://urn.nsk.hr/urn:nbn:hr:166:811997

Vancouver

Musa M. Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans [Doctoral thesis]. Split: University of Split, University of Split, Faculty of science; 2019 [cited 2023 February 09] Available at: https://urn.nsk.hr/urn:nbn:hr:166:811997

IEEE

M. Musa, "Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans", Doctoral thesis, University of Split, University of Split, Faculty of science, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:166:811997

Cite this item: https://urn.nsk.hr/urn:nbn:hr:166:811997

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Title	Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
Title (croatian)	Mehanizmi produljenja života uslijed toplinskog šoka u Saccharomyces cerevisiae i Caenorhabditis elegans
Author	Marina Musa
Mentor	Anita Kriško (mentor)
Mentor	Miroslav Radman (komentor)
Committee member	Sandra Sobočanec (predsjednik povjerenstva)
Committee member	Katarina Vukojević (član povjerenstva)
Committee member	Irena Drmić-Hofman (član povjerenstva)
Granter	University of Split University of Split, Faculty of science (Department of Physics) Split
Defense date and country	2019-10-07, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Interdisciplinary Natural Sciences
Universal decimal classification (UDC)	577 - Biochemistry. Molecular biology. Biophysics
Abstract	Aging is a process almost all known organisms undergo and it is accompanied by a general loss of function of all important physiological processes, including reduced resistance to cellular stress. While different stresses such as heat or oxidative stress are generally detrimental to the cell and the organism, if they are short and mild enough, they can benefit the organism and confer increased stress resistance later in life and prolong lifespan. This phenomenon is known as hormesis. By studying and comparing the response of the cell to heat stress in S. cerevisiae and C. elegans, we wanted to better understand what is necessary for the stress to produce a hormetic effect. Research into the molecular mechanisms of hormesis can give us a better picture of the processes required for the maintenance of stress resistance in cells, how it can be preserved or restored in aging cells, and its effects in lifespan.
Abstract (croatian)	Starenje je proces koji se događa u skoro svim poznatim organizmima, a prati ga opći gubitak funkcije svih značajnih fizioloških procesa, uključujući otpornost na stanični stres. Dok različiti stresori poput visoke temperature ili oxidativnog stresa su generalno pogubni za stanicu i organizam, ako je stres dovoljno kratak i blag, može imati pozitivan utjecaj na organizam, učiniti ga otpornijim na stres kasnije u životu, te produžiti životni vijek. Ovaj fenomen se naziva hormeza. Istražujući i uspoređujući stanični odgovor na toplinski stres u S. cerevisiae i C. elegans, željeli smo bolje razumjeti što je potrebno da stres proizvede hormetski efekt. Istraživanje molekularnih mehanizama hormeze nam može dati bolji uvid u procese koji su potrebni da bi stanica održala otpornost na stres, kako se otpornost na stres može održati ili čak povratiti u starijim stanicama, te njen utjecaj na životni vijek.
Keywords
Keywords (croatian)
Language	english
URN:NBN	urn:nbn:hr:166:811997
Study programme	Title: Postgraduate University Study of Biophysics Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resource	Text
Extent	110 str. ; 30 cm
File origin	Born digital
Access conditions	Open access Embargo expiration date: 2021-10-18
Terms of use
Repository	Repository of Faculty of Science
Created on	2019-11-04 12:57:09