Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale

Trgo, Gorana

prikaz prve stranice dokumenta Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale

Download
PDF 1.68 MB

doctoral thesis

Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale

Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:881204

Trgo, Gorana

University of Zagreb
Faculty of Science
Department of Biology

Cite this document

APA 6th Edition

Trgo, G. (2014). Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale (Doctoral thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:881204

MLA 8th Edition

Trgo, Gorana. "Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:881204

Chicago 17th Edition

Harvard

Trgo, G. (2014). 'Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 29 March 2023, https://urn.nsk.hr/urn:nbn:hr:217:881204

Vancouver

Trgo G. Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2023 March 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:881204

IEEE

G. Trgo, "Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:881204

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:881204

Please login to the repository to save this object to your list.

Metadata

Title	Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale
Title (english)	The role of asymmetric dimethylarginine (ADMA) response to oxidative damage in acute pancreatitis
Author	Gorana Trgo
Mentor	Maja Radman (mentor) MBZ: 224802
Mentor	Marijana Vučić Lovrenčić (sumentor) MBZ: 176744
Committee member	Marijana Popović Hadžija (član povjerenstva)
Committee member	Zoran Tadić (član povjerenstva)
Committee member	Miljenko Solter (član povjerenstva) MBZ: 74594
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2014, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Universal decimal classification (UDC)	577 - Biochemistry. Molecular biology. Biophysics
Abstract	Akutna upala gušterače (pankreatitis) praćena je oksidativnim i dušičnim stresom, no doprinos ovih mehanizama oštećenju tkiva i disfunkciji endokrinog dijela gušterače slabo je istražen. U ovom radu istraživana je uloga asimetričnog dimetilarginina (ADMA), endogenog inhibitora sintetaze dušičnog oksida (NOS), u razvoju oksidativno-dušičnog stresa te regulaciji glikemije na kliničkom modelu akutnog pankreatitisa. Rezultati razotkrivaju akutni pankreatitis kao stanje značajnog poremećaja glukoregulacije, pojačanog oksidativnog i dušičnog stresa te poremećene ADMA-om posredovane regulacije sinteze dušičnog oksida (NO). Hiperglikemija i oksidativno-dušični stres identificirani su kao mogući značajni uzroci smanjene bioraspoloživosti ADMA-e tijekom akutnog pankreatitisa, a intolerancija glukoze mjesec dana nakon preboljelog pankreatitisa, koja je nađena u 64% ispitanika, u izravnoj je vezi s razinom ADMA-e tijekom akutne faze bolesti. Do sada nepoznata nedostatna inhibicija sinteze NO u akutnom pankreatitisu značajno pridonosi oštećenju endokrine gušterače i kasnijem razvoju šećerne bolesti.
Abstract (english)	Acute pancreatitis is characterised by the oxidative and nitrosative stress, but contribution of these mechanisms to the tissue damage and endocrine pancreas dysfunction has been insufficiently studied. This study aimed to investigate the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide synthetase (NOS), in development of oxidative-nitrosative stress and potentially disturbed glucoregulation in the clinical model of acute pancreatitis. Results reveal acute pancreatitis as a condition associated with a significant derrangement of glucoregulation and increased oxidative-nitrosative stress, as well as a disturbed ADMAregulated nitric oxide (NO) synthesis. Both hyperglycaemia and oxidative-nitrosative stress were identified as potential significant determinants of decreased ADMA-bioavailibility during acute pancreatitis, while glucose intolerance, found in 64% of patients 1 month after acute pancreatitis, was found to be directly associated with ADMA-level during acute phase of illness. Sofar unrecognized insufficient inhibition of NO-synthesis in acute pancreatitis contributes significantly to the endocrine pancreas damage and might be responsible for subsequent development of diabetes mellitus.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:881204
Study programme	Title: Biology Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2017-05-18 11:50:41