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PDF 1.68 MB
doctoral thesis
5
9
The role of asymmetric dimethylarginine (ADMA) response to oxidative damage in acute pancreatitis
Gorana Trgo (2014)
University of Zagreb
Faculty of Science
Department of Biology
Cite this item:
https://urn.nsk.hr/urn:nbn:hr:217:881204
Metadata
Title
Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale
Author
Gorana Trgo
Mentor(s)
Maja Radman
Marijana Vučić Lovrenčić
Abstract
Akutna upala gušterače (pankreatitis) praćena je oksidativnim i dušičnim stresom, no doprinos ovih mehanizama oštećenju tkiva i disfunkciji endokrinog dijela gušterače slabo je istražen. U ovom radu istraživana je uloga asimetričnog dimetilarginina (ADMA), endogenog inhibitora sintetaze dušičnog oksida (NOS), u razvoju oksidativno-dušičnog stresa te regulaciji glikemije na kliničkom modelu akutnog pankreatitisa. Rezultati razotkrivaju akutni pankreatitis kao stanje značajnog poremećaja glukoregulacije, pojačanog oksidativnog i dušičnog stresa te poremećene ADMA-om posredovane regulacije sinteze dušičnog oksida (NO). Hiperglikemija i oksidativno-dušični stres identificirani su kao mogući značajni uzroci smanjene bioraspoloživosti ADMA-e tijekom akutnog pankreatitisa, a intolerancija glukoze mjesec dana nakon preboljelog pankreatitisa, koja je nađena u 64% ispitanika, u izravnoj je vezi s razinom ADMA-e tijekom akutne faze bolesti. Do sada nepoznata nedostatna inhibicija sinteze NO u akutnom pankreatitisu značajno pridonosi oštećenju endokrine gušterače i kasnijem razvoju šećerne bolesti.
Keywords
acute pancreatitis
diabetes
asymmetric dymethilarginine
reactive oxygen species
reactive nitrogen species
Parallel title (English)
The role of asymmetric dimethylarginine (ADMA) response to oxidative damage in acute pancreatitis
Committee Members
Marijana Popović Hadžija
(committee member)
Zoran Tadić
(committee member)
Miljenko Solter
(committee member)
Granter
University of Zagreb
Faculty of Science
Lower level organizational units
Department of Biology
Place
Zagreb
State
Croatia
Scientific field, discipline, subdiscipline
NATURAL SCIENCES
Biology
UDK
577
NATURAL SCIENCES
Biochemistry. Molecular biology. Biophysics
Study programme type
university
Study level
postgraduate
Study programme
Biology
Academic title abbreviation
dr.sc.
Genre
doctoral thesis
Language
Croatian
Defense date
2014
Parallel abstract (English)
Acute pancreatitis is characterised by the oxidative and nitrosative stress, but contribution of these mechanisms to the tissue damage and endocrine pancreas dysfunction has been insufficiently studied. This study aimed to investigate the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide synthetase (NOS), in development of oxidative-nitrosative stress and potentially disturbed glucoregulation in the clinical model of acute pancreatitis. Results reveal acute pancreatitis as a condition associated with a significant derrangement of glucoregulation and increased oxidative-nitrosative stress, as well as a disturbed ADMAregulated nitric oxide (NO) synthesis. Both hyperglycaemia and oxidative-nitrosative stress were identified as potential significant determinants of decreased ADMA-bioavailibility during acute pancreatitis, while glucose intolerance, found in 64% of patients 1 month after acute pancreatitis, was found to be directly associated with ADMA-level during acute phase of illness. Sofar unrecognized insufficient inhibition of NO-synthesis in acute pancreatitis contributes significantly to the endocrine pancreas damage and might be responsible for subsequent development of diabetes mellitus.
Parallel keywords (Croatian)
akutni pankreatitis
dijabetes
asimetrični dimetilarginin
reaktivni kisikovi radikali
reaktivni dušikovi spojevi
Version
accepted version
Resource type
text
Access condition
Open access
Terms of use
Note
accepted version
URN:NBN
https://urn.nsk.hr/urn:nbn:hr:217:881204
Committer
Palma Dizdarević