| Abstract | Cilj ispitivanja je ehokardiografska procjena funkcije desne klijetke srca u bolesnika sa
sustavnom sklerozom koji nemaju plućne hipertenzije te povezanost ehokardiokrafskih
parametara funkcije desne klijetke srca sa volumenom širine distribucije eritrocita
(RDW). Metode: U 21 ispitanika učinjeno je ehokardiografsko ispitivanje, a 19
ispitanika su praćeni prospektivno, longitudinalnim ispitivanjem u četiri
ehokardiografska mjerenja i mjerenjem RDW-a kroz godinu dana u četiri posjete (1.
mjesec, 4. mjesec, 8. mjesec, 12. mjesec).
Rezultati: U najvišoj tercilnoj RDW skupini (>14,25 u prvoj viziti) RV FAC bio je
značajno niži 48,00 (45,00-51,00) naspram 50,80 (49,08-53,40); P=0,023.u prvoj viziti,
te u najvišoj tercilnoj RDW skupini (>13,95 u drugoj viziti) PVAcct bio je značajno niži
u drugoj viziti. Korelacije izmjerenih vrijednosti RDW na prvoj viziti pokazuju značajno
srednje jaku pozitivnu korelaciju razine RDW-a s RIMP-om (rho=0,537, P=0,012) te
srednje jaku negativnu korelaciju RDW-a s PVAcct (rho=-0,495, P=0,023). Korelacije
izmjerenih vrijednosti RDW i na drugoj viziti pokazuju da razina RDW-a značajno
negativno korelira s PVAcct (rho=-0,497, P=0,022).
Zaključak: RDW u SSc može predstavljati integriranu mjeru multiplih patoloških
procesa uključujući preimarnu fibrozu miokarda i trajnu upalu. Više vrijednosti RDW-a
u bolesnika sa SSc mogu ukazivati na oštećenu kardiopulmonalnu funkciju i funkciju
desne klijetke srca no potrebna su daljna ispitivanja koja uključuju tkivno senzitivne
ehokardiografske metode. |
| Abstract (english) | Objective: The aim of this study was to evaluate echocardiographic parameters of right
ventricular function in patients with systemic sclerosis (SSc) without pulmonary
hypertension and its correlation to red cell distribution width (RDW).
Methods: 21 consecutive SSc patient undervent echocardiography with tissue Doppler
imaging to assess RV function. 19 study patients were investigated at baseline and in
four visits of one year follow up. Echocardiographic measuremets and RDW was
assessed at each visit (0-month visit, 4-month visit, 8-month visit, 12-month visit).
Results: In the highest tertile RDW group (>14,25 for first follow-up visit) RV FAC was
significantly lower 48,00 (45,00-51,00) compared to 50,80 (49,08-53,40); P=0,023.,
and in the highest tertile RDW group (>13,95 for second follow-up visit) PV Acct was
significantly lower (P=0,007) in the follow-up at first and second visit respectively. In
the highest tertile RDW group (>14,25 for first follow-up visit) RV FAC was significantly
lower 48,00 (45,00-51,00) compared to 50,80 (49,08-53,40); P=0,023., and in the
highest tertile RDW group (>13,95 for second follow-up visit) PV Acct was significantly
lower (P=0,007) in the follow-up at first and second visit respectevely. RDW showed a
positive correlation with RIMP (rho=0,537, P=0,012) on the first visit and negative
correlation with PVAcct on the firs (rho=-0,495, P=0,023) and second (rho=-0,497,
P=0,022) visit during the follow-up, respectively.
Conclusion: RDW in SSc may represent an integrative measure of multiple
pathological processes including fibrosis and ongoing inflammation. An increase in
RDW may indicate an impairment of cardiorespiratory function and right ventricular
function but further investigation is needed. |
