prikaz prve stranice dokumenta Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze
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doctoral thesis
Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze
Zagreb: University of Zagreb, School of Medicine, 2014. urn:nbn:hr:105:905818
Mirošević Skvrce, Nikica
University of Zagreb
School of Medicine

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Mirošević Skvrce, N. (2014). Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:905818

Mirošević Skvrce, Nikica. "Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze." Doctoral thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:905818

Mirošević Skvrce, Nikica. "Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze." Doctoral thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:905818

Mirošević Skvrce, N. (2014). 'Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze', Doctoral thesis, University of Zagreb, School of Medicine, accessed 26 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:905818

Mirošević Skvrce N. Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2014 [cited 2024 April 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:905818

N. Mirošević Skvrce, "Utjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:105:905818

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Metadata
TitleUtjecaj farmakogenetičkih varijacija metaboličkih enzima i transportnih proteina na nastanak nuspojava inhibitora 3-hidroksi-3-metil-glutaril koenzim A (HMG-CoA) reduktaze
AuthorNikica Mirošević Skvrce
VIAF: 305727507
Mentor Nada Božina (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2014-06-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Inhibitori 3-hidroksi-3-metil-glutaril-koenzim-A (HMG-CoA) reduktaze (statini) najpropisivaniji su lijekovi u liječenju hiperkolesterolemije. U velikom broju kliničkih ispitivanja dokazana je njihova učinkovitost u smanjivanju rizika nastanka kardiovaskularnog događaja. Međutim, statini mogu imati i ozbiljne nuspojave kao što su miopatija i rabdomioliza. Novi identificirani rizični faktori za nastanak toksičnosti statina su genetičke varijante metaboličkih enzima i prijenosnika. Glavni cilj rada bio je odrediti učinak genskih varijanti CYP2C9, ABCB1, ABCC2, ABCG2 i SLCO1B1 na nastanak nuspojava povezanih s primijenjenom dozom simvastatina, atorvastatina i fluvastatina. U studiju je bilo uključeno 162 bolesnika koji su iskusili nuspojave povezane s dozom atorvastatina, fluvastatina i simvastatina te 162 bolesnika koji su uzimali ispitivane statine i nisu iskusili nuspojave (kontrolna skupina). Kontrolna skupina ispitanika je prema godinama, spolu, dozi i primjeni ciklosporina odgovarala bolesnicima koji su razvili nuspojavu. Rezultati studije pokazuju kako su varijante gena ABCG2 421C>A i CYP2C9*3 povezane s nastankom nuspojava fluvastatina, a varijante gena ABCG2 421C>A i SLCO1B1 521 C>A s nuspojavama atorvastina i simvastatina. Naša studija je prva povezala varijante gena ABCG2 s nastankom nuspojava statina. Naša je studija također prva ispitala i pokazala važnost farmakogenetičke predispozicije za nastanak nuspojava fluvastatina.
Abstract (english)
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used for the treatment of hypercholesterolemia. Their efficacy in preventing cardiovascular events has been shown by a large number of clinical trials. However, adverse drug reactions (ADRs), sometimes serious, including myopathy or rhabdomyolysis, are associated with the use of statins. Newly identified risk factors for statin induced toxicity are genetic variants of drug metabolizing enzymes and membrane transporters. The aim of our study was to show influence of ABCB1, ABCC2, ABCG2, SLCO1B1 and CYP2C9 gene variants on development of atorvastatin, simvastatin and fluvastatin induced, dose related ADRs. One hundred sixty two patients that experienced statin induced ADRs and 162 controls matched for age, gender, dose and cyclosporine use were enrolled in the study. We found that ABCG2 421C>A and CYP2C9*3 variants were associated with fluvastatin induced ADRs, ABCG2 421C>A and SLCO1B1 521 C>A variants were associated with simvastatin and atorvastatin ADRs. Our study first linked statin ADRs and ABCG2 variants. Also, our study first showed importance of pharmacogenetic predisposition for developing fluvastatin ADRs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:905818
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent91 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryDr Med - University of Zagreb School of Medicine Digital Repository
Created on2023-05-05 07:20:51

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