Aim: The purpose of this study was to evaluate the effectiveness of high-energy diode LaserHF; Er,Cr:YSGG; Er:YAG and Nd:YAG lasers in surgical treatment of benign oral lesions compared to conventional surgical methods, and to monitor and compare temperature differences and changes during laser surgery. Materials and methods: The study included 250 patients, randomly divided into 5 groups. The temperature of the treated area was recorded using a Flir T335 thermographic camera before, during and after the treatment. Thermographic readings were subsequently made on the basis of recorded thermographs. On the third and seventh postoperative day, the patients completed the OHIP-CRO 14 Patient Satisfaction Questionnaire. Results: The results indicate that there are statistically significant thermographic differences (p<0.05) during and after the intervention between different laser groups. There was a statistically significant difference in the postoperative quality of life (OHIP-CRO 14) (p<0.01) between the patients in the test groups who had undergone laser therapy to have intraoral benign lesions removed and the control group. The results showed that the Er: YAG laser had statistically significantly lower intensitiy of heating of the surrounding tissue during and after therapy (p <0.05). There is no statistically significant difference in the postoperative course and the length of recovery between the patients who had undergone laser tratment and those who were treated using the conventional method (p> 0.05). Conclusion: Er:YAG (λ=2940 nm) and Er,Cr:YSGG (λ=2780 nm) lasers generate lower levels of heat compared to diode and Nd:YAG lasers and may provide safer surgery of soft tissues without destructive effects of temperature increase. There is a difference in wound healing after surgical removal of benign lesions using a laser and conventional surgery; however it is not statistically significant. There is a difference in pain intensity after the procedure depending on therapeutic protocol used. Recovery after the procedure and return of quality of life to the preoperative level differs depending on the therapeutic protocol. There is a statistically significant difference between four laser test groups in energy dissipation and the temperature of the surrounding tissues after the therapy. This research confirms that when high-energy lasers are used, cooling with water and air is necessary to reduce the temperature rise in the operating area.