|Sažetak rada|| |
Dijabetička polineuropatija (DPN) najčešća je komplikacija dijabetesa, a može biti prisutna s i
bez neuropatke boli uz poznatu pojavu depresivnih simptoma u dijabetičara. Kvaliteta života
ključan je parametar na osnovi koje je moguće dati objektivnu procjenu stanja bolesnika, ali i
predvidjeti daljnji tijek bolesti kao i uspjeh liječenja.
Cilj ovog istraživanja je ispitati da li bolna dijabetička polineuropatija i prisutna depresija
značajno utječu na smanjenje kvalitete života bolesnika sa šećernom bolešću.
Ispitanici i metode
Istraživanje je provedeno u KB Merkur- Sveučilišnoj klinici „Vuk Vrhovac“. U istraživanje je
uključeno 240 bolesnika – od kojih 80 bolesnika ima bolnu dijabetičku neuropatiju, 80
bolesnika dijabetičku neuropatiju bez boli, a 80 ispitanika su bolesnici koji su liječeni u KB
Merkur zbog križobolje, ali bez dijabetesa. Kvaliteta života ispitanika ispitivana je SF – 36
(Short Form Health Survey) upitnikom. Za procjenu simptoma i znakova neuropatske boli u
ispitanika korištene su dvije ljestvice VAS (visual analogue scale) i LANSS (Leeds
Assessment of Neuropathic Symptoms and Signs) ljestvica, a za probir depresivnosti
upotrijebljen je BDI -II (Beck Depression Inventory) upitnik.
Vidljivo je da postoji izrazita negativna linearna korelacija jačine boli i kvalitete života u svim
promatranim slučajevima. Korelacija je bila statistički značajna za sve dimenzije SF-36 i za
sva tri načina evaluacije boli, kao i za prisutnost depresivnih simptoma.
U skupini dijabetičara s bolnom DPN statistički je značajno jače prisutna bol kao i depresivni
poremećaji, što omogućuje donošenje zaključka da su upravo bol i depresivni poremećaji
uzrokom konstantno niže kvalitete života u ovih bolesnika.
|Sažetak rada na drugom jeziku (engleski)|| |
Neuropahtic pain is defined by IASP as pain that occurs as a direct result of lesions or disease
affecting somatosensory system. Diabetic Peripheral Neuropathy (DPN) is the most common
complication of diabetes and may be found with and without neurophatic pain. It increases
with duration of diabetes. There is also occurrence of depressive symptoms with persons with
diabetes. Quality of life is a key parameter on which to base an objective assessment of the
patient’s condition but also to predict the future course of the disease and the success of
Objective The aim of this study was to examine whether Diabetic Peripheral Neuropathy and
present depression significantly impact reduction in quality of life in diabetic patients.
Subjects and Methods The study was conducted in Clinical Hospital Merkur- University
Clinic "Vuk Vrhovac" Reference centre for health care of persons with diabetes of Croatian
Ministry of Health and WHO collaborating institution. The study included 240 patients, 80 of
which had been diagnosed with painful diabetic neuropathy (group B), 80 patients with
diabetic neuropathy without pain (group D). The remaining 80 patients (control group K)
were the patients who were treated in Clinical Hospital Merkur because of back pain and the
diagnosis of DPN was excluded.
In addition to a complete neurological examination included in the General Questionnaire on
the Subject, demographic data was also collected. The EMNG tests of arms and legs were
conducted, Doppler Ultrasound of leg artery, CDFI of carotid arteries and, when necessary,
X-ray, CT or MRI test of lumbosacral spine. The quality of life of the subjects was questioned
using the SF - 36 (Short Form Health Survey). For the assessment of symptoms and signs of
neuropathic pain in patients two VAS (visual analogue scale) scales were used for current
pain and pain during the past month and LANSS (Leeds Assessment of Neuropathic
Symptoms and Signs) scale. Breakthrough of depression was tested by BDI-II (Beck
Depression Inventory) survey.
Results The average age of the subjects was 60.8 years (59.4 +/- 62.2 y). The study included
128 women and 112 men. Most of the subjects diagnosed with diabetes (group B and D)
suffered from type II diabetes (87.4%). The average duration of disease was 18 years.
Subjects with type I diabetes were significantly younger (49.5 years of age) than patients with
type II diabetes (64.2 years of age). In subjects with type I diabetes the average duration of
disease was longer (23.6 years) than in subjects with type II diabetes (17.2 years). Persons
with diabetes without painful DPN suffered more often from type I diabetes compared to the
subjects with painful DPN. As regards to the therapy they were taking, the majority of
subjects (50.6%) were on insulin therapy, around one quarter of the subjects were either on a
combination of peroral and insulin therapy (22.2%) or on a peroral therapy alone (27.2%).
There were statistically significant differences of subjects by type of polyneuropathy
according to the age, i.e. more severe forms were noticed in the older subjects. In 90.4% of
subjects pain occurred couple of years before. In the past month, most of the subjects (47.1%)
had pain every day, followed by those who had pain several times a week (33.8%) or several
times a month. According to the parameter of the current intensity of pain, the highest figures
were found in group B - 5.9 points VAS, and the lowest - 3.1 points VAS in Group D. The
test of degree of pain during the previous month recorded similar results; the highest amount
of 7.1 points VAS found in group B, and the lowest of 3.9 points VAS found in group D. By
gender, women experienced pain significantly stronger than men. This applies both to current
pain (4.8 versus 3.8 points), and pain during the previous month (6.5 versus 4.7 points).
Current pain was significantly and linearly related to age, but not as regards to the pain during
the past month. LANNS scale showed that the subjects of the study had an average of 12.2
points. According to Beck scale (revision II), the subjects got an average of 13.4 points. In
both observed scales women showed on average statistically much higher figures of pain and
depression than men. The stronger the pain that the subjects felt the stronger level of
depression was found. It is interesting to note that the strongest correlation was found between
the degree of pain during the past month according to the VAS scale. It can be concluded that
the degree of pain determined in this manner is the best predictor of the level of depression in
The largest share of the subjects controlled defecation and urination (84.5%), while only a
very small proportion of subjects controlled it partially or had not at all been able to control it.
In women, the defecation and urination control was significantly weaker than in men. The
same was found for sleep, whereas the women showed worse results. Accordingly, in group
D, it was found that the highest number of subjects (85%) described their sleep as good, quite
the opposite of group B with only 18.75% of subjects describing their sleep as good. The
average number of medication, analgesics, was the highest in Group B (2.1), followed by the
group K (1.7), while the lowest average number of persons taking medication was found in
the subjects from the group D (1,2).
By observing the results in all eight dimensions of the SF-36 scale, it is evident that the
subjects from the general population had higher average results in all dimensions. On the
basis of such comparison it is possible to conclude that the subjects of this study had on
average lower quality of life than would be expected by observing the figures recorded in the
general population. In all dimensions except for GH (general health perceptions), the lowest
average figures were found in group B, and the highest in group D and the subjects from the
Group K showed middle result figures compared to these two groups. It is also interesting to
note that in four dimensions (VT, SF, RE and MH), the subjects of Group D showed higher
average figures when compared to those found in the general population. The correlation of
all 8 dimensions of the SF-36 scale with all three variables used to assess the degree of pain
during the study with the results of the BDI scale was confirmed. It is evident that there is a
strong negative linear correlation between intensity of pain and quality of life in all observed
cases. The correlation was statistically significant for all dimensions of the SF-36, and for all
three methods of pain evaluation, and the presence of depression symptoms.
Conclusion The primary hypothesis - pain and depressive symptoms significantly impact the
quality of life in patients with painful diabetic polyneuropathy was confirmed. The positive
and statistically significant correlation between the two parameters, depression and pain, with
all eight of the observed dimensions of quality of life of SF 36 survey lead to the conclusion
that pain and depression caused a constantly lower quality of life in these patients.