The aim of the study was to estimate relationship of insight into the disease and internalized selfstigma on depression and suicidality. The study was conducted using cross-sectional method among 149 patients diagnosed with schizophrenia who were treated at the University Psychiatric Hospital Vrapče in Zagreb, July 2012 to December 2014. The diagnosis of schizophrenia was set by two independent psychiatrists according to diagnostic criteria of ICD-10 and DSM-IV. For each patient socio-demographic and hospital data were gathered. Observed clinical features were objectified using PANSS, CGI, ISMI (Internalized stigma in Mental Illness), SUMD (Scale to Assess Unawareness of Mental Disorder), CDSS (Calgary Depression Scale for Schizophrenia), ISST (InterSePT Scale for Suicidal Thinking), BCS (Beck's Hopelessness Scale), and WHOQOL-BREF (WHO Quality of Life-BREF). Regarding insight into illness statistically significant difference was found between in the intensity of psychopathology, general clinical impression, depression, suicidality, hopelessness and quality of life. Regarding internalized selfstigma statistically significant difference was found between in the intensity of psychopathology, general clinical impression, depression, suicidality, hopelessness and quality of life. The study confirmed hypothesis that internalized selfstigma moderates relationship between better insight into illness and depression. The hypothesis that greater insight into the disease and internalized selfstigma has an impact on depression, suicide, hopelessness and lower quality of life. Moderating role of internalized selfstigma on relationship between insight into illness and suicidality was not found.