Aim of this study was to determine presence of eventual differential specificities between patients with paranoid schizophrenia who are perpetrator of criminal offence and ones who aren’t. Research was made on a sample of 122 patients with diagnosis of paranoid schizophrenia F20.0, 61 of them were perpetrators of criminal offence and they were treated by the court order, and 61 weren’t perpetrators of criminal offence and they were treated by indications for hospital treatment. Participants were equaled by gender, age and education. All participants were tested by questionnaires: Wechsler WB for analyzing intellectual abilities, MMPI-201 for analyzing pathological characteristics of personality, Eysenck’s Personality Questionnaire (EPQ_RA), Freiburg Personality Inventory (FPI), Life Style Index (LSI), Temperament and Character Inventory (TCI) and Sociodemographic Data Questionnaire. Set of diagnostic measure instruments was used to try to determine presence of interdependence of psychopathological symptoms and other factors from possible impact on perpetration of criminal offence, and to correlate it with a group of non-perpetrators of criminal offence in same diagnostic category. Ultimate aim of this study was to determine eventual factors which would be significant in prediction of future criminal behavior. Researches show that paranoid-schizophrenic perpetrators of criminal offence are significantly more present in a category of violent criminality, including homicide, in relation to distribution of perpetration of criminal offence in general population. Perpetrators’ of criminal offence victims are mostly within family and relatives population. In a group of perpetrators of criminal offence there is comorbidity of more personality disorders, earlier prison experience and earlier forensic treatment, impact of psychoactive substances tempore acti, and in a group of non-perpetration of criminal offence there is more alcohol addictions, but without statistical significance. In this research presence of psychopatological and criminal specificities are comfirmed in criminal defense perpetrators wich differ them from non-perpetrators of criminal defense.Three predicting models significant in prediction of criminal defense were identified. We consider results of this study more as probable tendencies than firm facts, so this study refer to further research in specific behavior of paranoid-schizophrenic patients, on a greater pattern, to enable usage of preventive and therapeutic programs for this group of patients adequately and on time.