Introduction: The fixed orthodontic appliances may enhance plaque accumulation and lead to the progress of both demineralization and caries lesions, especially in patients with inadequate oral hygiene. Further, white spot lesion (WSL) can be seen after just four weeks of a fixed orthodontic appliance being fitted. The overall prevalence of WSLs ranges from 2– 96% depending on the assessment procedure of assessment of the lesions, whether or not any such defects were present before treatment and whether or not fluoride supplements were used during treatment. The altered enamel structure of teeth with initial caries lesions may reduce the shear bond strength (SBS) between orthodontic brackets and the enamel surface at the beginning of orthodontic treatment, as well as during treatment if the rebonding of the brackets is required. If bracket bonding is to be performed on demineralized enamel, it is advisable to stabilize and protect the demineralized enamel lesion prior to the reapplication of the bracket. Prior research reveal that low-viscosity resin is able to significantly penetrate initial caries lesions, which leads to their stabilization. The optical appearance of WSLs was also found to be improved by resin infiltration, with the achieved concealment being shown to remain stable in one-year interval in vivo. Aim: The aim of the present study was to assess the SBS of orthodontic brackets bonded with different adhesives to demineralized human enamel that had been treated with a low-viscosity resin infiltrant. It also aimed to compare the achieved bond strengths to those achieved in relation to sound enamel, as well to compare the ARI score between the four tested groups. Materials and methods: A total of 48 newly extracted third molars were collected, randomly allocated in four groups (n= 12), covered with a nail varnish, with 4 x 4 mm of uncoated area. Groups 2, 3 and 4 were immersed in Buskes demineralizing solution (14 days, 37 ºC) and Group 1 remained untreated. Group 1: sound enamel + Transbond XT; Group 2: demineralised enamel + ICON + Transbond XT; Group 3: demineralised enamel + ICON + Scotchbond Universal; Group 4: demineralised enamel + ICON + Assure Plus. Prior to adhesive application all the specimens were etched with 37% phosphoric acid for 15s. In all groups molar tubes were bonded with Transbond XT Paste. Prior to SBS testing, all the specimens were thermocycled (10,000 times Marina Šimunović Aničić, disertacija between 50 ∘C and 55 ∘C). SBS was measured in MegaPascals (MPa) and statistically analysed (ANOVA, p ≤ 0.05). The mode of failure was assessed microscopically at 10xmagnification. Results: The highest bond strength (20.3 MPa) was measured by molar tubes bonded with Assure Plus on demineralized enamel and the difference was statistically significant (p ≤ 0,001). No statistically significant differences were found among Groups 1, 2 and 3. No statistically significant between-group difference was observed for ARI scores. Conclusion: Based on our research, there is no evidence that resin infiltrated demineralized enamel surface reduces the SBS of the orthodontic brackets. Thus, the bonding of the orthodontic elements with the adhesive system on the infiltrated area can be performed without risk of reducing the SBS. SBS measured in the Assure PLUS group was significantly higher compared to two other groups (Transbond XT and Scotchbond) as well as the control group.