Background and objectives: Hyposalivation is a state of reduced secretion of saliva which can be caused by drugs, by radiation to the head and neck in order to treat head and neck cancers, and can occur in some systemic diseases such as Sjogren's syndrome, etc. Hyposalivation is a very annoying symptom for patients as it is constantly present, thus preventing speech, chewing and swallowing. In addition to these, there is a stronger tendency to develop caries, gingivitis and candidiasis due to lack of saliva. In the literature around the world there are various local and systemic preparations to facilitate the symptoms of dry mouth in patients, although each of them has advantages and disadvantages. The aim of this study was to compare the efficacy of acupuncture, low level laser therapy (LLLT) and water in 67 patients with hyposalivation caused by drugs. Methods: Before therapies each participant filled out a questionnaire on the quality of life in the Croatian language (OHIP-14 CRO) and the amount of saliva was measured by simple method of ejecting saliva into calibrated tubes for 5 minutes in the morning between 8 and 11 A.M. Both procedures were repeated after the completion of each therapy. Low Level Laser Therapy (GaAlAs, 830 nm wavelength; dose 1,80 J/cm2; power 35 mW, area 4 cm2, frequency 5,20 Hz, pulse 800 ms; period 1 ms) was carried out every working day in the course of 14 days and each session lasted 15 minutes on the skin area above the major salivary glands in 28 patients. In 16 participants of the control group, LLLT was conducted with laser device which was switched off. Acupuncture was performed by use of needles (0,16x10mm) inserted on the following points; Shen Man, Point Zero, Autonomic Point, Thirst Point, Salivary Gland F on both ears while the participants were sitting for 30 minutes at the acupuncturist. After the participants got press needles (0,16x1,4 mm) on one ear at the points Shen Men and Thirst Point till the next session. Second acupuncture session was one week after the first one and the remaining three every seven days. Statistical analysis was performed by use of Student t test for dependent and independent samples. Results: The results of this study have shown that acupuncture was superior in comparison to the LLLT and switched off LLLT on the basis of increased salivary flow rate and the quality of life questionnaire. LLLT increased salivary flow rate, however, there was no significant improvement in scores of the quality of life questionnaire. LLLT, when switched off, did not increase salivary flow rate nor OHIP-CRO scores significantly. Conclusion: We might conclude that salivary gland stimulation by use of acupuncture increased salivary flow rate in patients with drug-induced hyposalivation as well as improved scores of OHIPCRO. Switched on LLLT also increased salivary flow rate in these patients, however OHIP CRO scores were not signifiantly different. Switched of LLLT neither increased salivary flow rate nor improved OHIP-CRO scores.