Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim  protutijelom  trastuzumabom

Vazdar, Ljubica

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doctoral thesis

Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom

Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:505019

Vazdar, Ljubica

University of Zagreb
Faculty of Science

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APA 6th Edition

Vazdar, Lj. (2017). Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom (Doctoral thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:505019

MLA 8th Edition

Vazdar, Ljubica. "Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:505019

Chicago 17th Edition

Harvard

Vazdar, Lj. (2017). 'Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 21 March 2023, https://urn.nsk.hr/urn:nbn:hr:217:505019

Vancouver

Vazdar Lj. Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2023 March 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:505019

IEEE

Lj. Vazdar, "Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:505019

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:505019

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Title	Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom
Title (english)	Influence of HER-2/neu gene polymorphism on monoclonal antibody trastuzumab induced cardiotoxicity
Author	Ljubica Vazdar
Mentor	Hrvoje Pintarić (mentor) MBZ: 224771
Committee member	Sonja Levanat (predsjednik povjerenstva)
Committee member	Ana Galov (član povjerenstva)
Granter	University of Zagreb Faculty of Science Zagreb
Defense date and country	2017, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Universal decimal classification (UDC)	57 - Biological sciences. Physical anthropology. Biodiversity
Abstract	Malobrojna dosadašnja istraživanja pokazala su dvojbene rezultate utjecaja polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom. Obzirom na izuzetno važan biljeg u onkologiji i mogući čimbenik rizika srčanog oštećenja, nametnula se potreba ovakvog istraživanja. U istraživanje su uključene ispitanice adjuvantno liječene trastuzumabom zbog HER2 pozitivnog ranog raka dojke (n=177). Ispitanice su podijeljenje u dvije grupe: grupa A (n=99) kod kojih nije došlo do kardiotoksičnosti tijekom liječenja trastuzumabom i grupa B (n=78) kod kojih je došlo do razvoja kardiotoksičnosti. Istraženi su rizični čimbenici kao i osobitosti same kardiotoksičnosti, vrijeme pojavnosti i oporavka te reverzibilnost. Svim ispitanicama je lančanom reakcijom polimeraze određen polimorfizam gena HER-2/neu na kodonu 655 [Ile655Val] te distribucija genotipa Ile/Val, Ile/Ile i Val/Val. Praćenje srčane funkcije ehokardiografijom bilo je u skladu s usvojenim smjernicama praćenja. Iz rezultata dobivenih usporedbom grupa A i B nije nađena povezanost između pojedinog genotipa HER-2/neu i pojave kardiotoksičnosti.
Abstract (english)	A few studies so far have shown doubtful results on influence of HER-2/ neu gene polymorphism on cardiotoxicity caused by monoclonal antibody trastuzumab. Remarkable importance of this marker in oncology and its place as a possible risk factor for cardial damage, imposed the need for this kind of research. The study included patients adjuvantly treated with trastuzumab for HER2 positive breast cancer (n = 177). Subjects were divided into two groups: group A (n = 99), which did not experience cardiotoxicity during treatment with trastuzumab and group B (n = 78) which did. Risk factors were investigated as well as the characteristics of cardiotoxicity, time of occurrence and recovery, and reversibility. Polymorphism of the HER-2/ neu gene on codon 655 [Ile655Val] and Ile/Val, Ile/Ile and Val/Val genotype distribution was determined by polimerase chain reaction in all patients. Heart function monitoring with echocardiography was consistent with the adopted monitoring guidelines. From the results obtained by comparing groups A and B, no correlation was found between HER-2/neu genotype and cardiotoxicity.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:505019
Study programme	Title: Biology Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2017-11-02 12:41:43