prikaz prve stranice dokumenta Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke
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doctoral thesis
Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:486090
Lež, Cvjetko
University of Zagreb
Faculty of Science
Department of Biology

Cite this document

Lež, C. (2013). Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:486090

Lež, Cvjetko. "Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:486090

Lež, Cvjetko. "Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:486090

Lež, C. (2013). 'Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:486090

Lež C. Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:486090

C. Lež, "Odnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:486090

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Metadata
TitleOdnos ekspresije matriks metaloproteinaze-2 i p63 s peritumorskim pukotinama u karcinomu dojke
Title (english)The correlation between matrix metalloproteinase-2 and p63 expression and peritumoral retraction clefting in breast carcinoma
AuthorCvjetko Lež
MentorBožo Krušlin (mentor)
MBZ: 177914
Committee memberSonja Levanat (član povjerenstva)
Committee memberBožo Krušlin (član povjerenstva)
MBZ: 177914
Committee memberGordana Lacković-Venturin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Istraživanjem je analizirana pojava peritumorskih pukotina u duktalnom invazivnom karcinomu dojke, ekspresija matriks metaloproteinaze-2 i p63 u tumorskim stanicama te povezanost pojave peritumorskih pukotina s ekspresijom matriks metaloproteinaze-2 i p63. Također je analizirana korelacija pojave peritumorskih pukotina te ekspresije matriks-mateloproteinaze-2 i p63 s ostalim obilježjima tumora - uključujući dob bolesnica, histološki gradus, veličinu tumora, status pazušnih limfnih čvorova, TNM klasifikaciju, stadij bolesti, ekspresiju estrogenskih i progesteronskih receptora te ekspresiju proteina Her2/neu. Rezultati istraživanja pokazuju da se peritumorske pukotine statistički značajno češće pojavljuju kod starijih bolesnica (p=0,010) i u većim tumorima (p=0,018). Nije nađena statistički značajna povezanost ekspresije matriks metaloproteinaze-2 s pojavom peritumorskih pukotina niti u odnosu na ostala promatrana obilježja. Pozitivna ekspresija p63 je nađena u samo jednom karcinomu, histološkog gradusa III. Pozitivna ekspresija p63 u mioepitelnim stanicama okolnog zdravog tkiva dojke, te izostanak imunoreaktivnosti u karcinomima s peritumorskim pukotinama, upućuje na povezanost pojave peritumorskih pukotina s gubitkom mioepitelnih stanica.
Abstract (english)
In this study we analyzed the presence and correlation of peritumoral retraction clefting and the expression of matrix metalloproteinase-2 (MMP-2) and p63 in invasive ductal breast carcinoma. The occurrence of peritumoral clefting and expression of MMP-2 and p63 was also correlated to patient age, tumor size and histological grade, axillary lymph node status, TNM stage, stage of the disease and the expression of Her2/neu, estrogen and progesterone receptors. The results show a statistically significant higher occurrence of peritumoral clefting in older patients (p=0,010) and larger tumors (p=0,018). The expression of MMP-2 did not show statistically significant correlation to peritumoral clefting nor to other parameters. p63 expression was found only in one grade III carcinoma. p63 expression in the myoepithelial cells of the surrounding normal breast tissue and the lack in carcinomas showing peritumoral clefting, indicates the correlation between the loss of myoepitelial cells and the occurrence of peritumoral retraction clefting.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:486090
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Science
Created on2017-05-19 09:06:31

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