Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke

Alvir, Ilija

prikaz prve stranice dokumenta Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke

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doctoral thesis

Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke

Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:683477

Alvir, Ilija

University of Zagreb
Faculty of Science
Department of Biology

Cite this document

APA 6th Edition

Alvir, I. (2015). Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:683477

MLA 8th Edition

Alvir, Ilija. "Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:683477

Chicago 17th Edition

Harvard

Alvir, I. (2015). 'Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 16 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:683477

Vancouver

Alvir I. Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 April 16] Available at: https://urn.nsk.hr/urn:nbn:hr:217:683477

IEEE

I. Alvir, "Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:683477

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:683477

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Metadata

Title	Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke
Title (english)	Role of hypoxia in the development of triple negative invasive ductal breast carcinoma
Author	Ilija Alvir
Mentor	Lidija Beketić-Orešković (mentor) MBZ: 143056
Committee member	Nada Oršolić (član povjerenstva)
Committee member	Sonja Levanat (član povjerenstva)
Committee member	Božena Šarčević (član povjerenstva) MBZ: 87995
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2015, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Universal decimal classification (UDC)	57 - Biological sciences. Physical anthropology. Biodiversity
Abstract	Karcinom dojke najzastupljeniji je tip karcinoma u žena. Brojni tumorski pokazatelji koriste se za praćenje karcinoma dojke: veličina, multicentričnost, histološki tip i gradus, status estrogenskih i progesteronskih receptora (ER i PR), HER2 status, limfovaskularna invazija, pozitivni limfni čvorovi aksile i prisutne udaljene metastaze. Trostruko negativan karcinom dojke (eng. triple negative breast cancer, TNBC) najagresivniji je podtip karcinoma dojke s visokom stopom recidiva i lošijim preživljenjem bolesnica. Tumorska hipoksija važan je pokazatelj prognoze maligne bolesti povezana s agresivnijim rastom, ranijim metastaziranjem i lošim odgovorom tumora na liječenje. U hipoksičnim uvjetima dolazi do pojačane izraženosti p53 i indukcije apoptoze preko Bcl-2. Imunohistokemijskom metodom istraživana je povezanost biljega stanične hipoksije karboanhidraze IX (CAIX), Bcl-2, p53 i Ki-67 s pokazateljima agresivnosti karcinoma. Rezultati pokazuju da je istraživani biljeg hipoksije CAIX u statistički značajnoj pozitivnoj korelaciji s p53 te s biljegom proliferacije Ki-67. Protein p53 u pozitivnoj je korelaciji s veličinom tumora te granično s gradusom. Biljeg apoptoze Bcl-2 nije u korelaciji s ostalim ispitivanim biljezima kao ni s pokazateljima agresivnosti karcinoma. Istraživanje je potvrdilo da TNBC imaju agresivnije ponašanje od samog početka. S obzirom da velika većina TNBC ima izražene biljege hipoksije, neki od tih biljega mogli bi biti dio ciljane terapije.
Abstract (english)	Breast cancer (BC) is the most common type of cancer in women. Numerous tumor indicators are used to monitor BC: size, multicentricity, histological type and grade, status of estrogen and progesterone receptors (ER and PR), HER2 status, lymphovascular invasion, positive axillary lymph nodes and presence of distant metastases. The triple negative breast cancer (triple negative breast cancer, TNBC) is very aggressive subtype of BC with a high rate of recurrence and poor survival. Tumor hypoxia is an important indicator of malignant disease prognosis, associated with aggressive growth, early metastasis and poor response to treatment. In hypoxic conditions an increased expression of p53 occurs along with induction of apoptosis via Bcl-2. Using immunohistochemical methods, we investigated the correlation of expression of cellular hypoxia markers, carbonic anhydrase IX (CAIX), Bcl-2, p53 and Ki-67 with indicators of cancer aggressiveness. The results indicated that investigated hypoxia marker CAIX is in statistically significant positive correlation with both p53 and Ki-67. Only p53 was correlated with any of investigated marker. Apoptotic marker Bcl-2 is more expressed at larger tumors. This study confirmed that TNBC have aggressive behavior from the very beginning. Since the vast majority of TNBC expressed markers of hypoxia maybe some of these markers have potential for development targeted therapies.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:683477
Study programme	Title: Biology Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resource	Text
File origin	Born digital
Access conditions	Closed access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2017-05-16 11:46:38

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