Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)

Vojvoda Parčina, Valerija

prikaz prve stranice dokumenta Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)

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doctoral thesis

Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)

Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:746737

Vojvoda Parčina, Valerija

University of Zagreb
Faculty of Science
Department of Biology

Cite this document

APA 6th Edition

Vojvoda Parčina, V. (2016). Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV) (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:746737

MLA 8th Edition

Vojvoda Parčina, Valerija. "Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:746737

Chicago 17th Edition

Harvard

Vojvoda Parčina, V. (2016). 'Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:746737

Vancouver

Vojvoda Parčina V. Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV) [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:746737

IEEE

V. Vojvoda Parčina, "Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:746737

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:746737

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Metadata

Title	Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)
Title (english)	Th1 and Th2 associated chemokines and chemokine receptors in RSV infection
Author	Valerija Vojvoda Parčina
Mentor	Krešo Bendelja (mentor)
Committee member	Nada Oršolić (član povjerenstva)
Committee member	Mirjana Turkalj (član povjerenstva)
Committee member	Snježana Židovec-Lepej (član povjerenstva) MBZ: 228211
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2016, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Universal decimal classification (UDC)	577 - Biochemistry. Molecular biology. Biophysics
Abstract	RSV (engl. respiratory syncytial virus) je najčešći uzročnik respiratornih infekcija djece do druge godine. Razvoj težih oblika bolesti i česte reinfekcije mogu se povezati s istovremenim razvojem antivirusne Th1 i nepoželjne Th2 imunoreakcije. Th1 imunoreakcija je povezana s povišenom proizvodnjom IFN-γ te kemokina CXCL10 i CXCL9, dok je Th2 povezana s proizvodnjom IL-4 odnosno CCL17 i CCL22. U djece s akutnom RSV-infekcijom smo lokalno i sistemski odredili kemokinski profil obzirom na tip-1 i tip-2 imunoreakcije te ekspresiju specifičnih kemokinskih receptora (CXCR3 i CCR4) na T-limfocitima. Radi boljeg uvida u usmjeravanje diferencijacije T-limfocita u tip-2, određena je ekspresija CRTh2-receptora. Rezultati su pokazali da RSV specifično podiže razinu CXCL10 i CCL17 tijekom akutne infekcije. Neodgovarajući razvoj memorijske imunosti popraćen je povećanim postotkom TEM-limfocita tipa-1 i tipa-2, te izostankom razvoja dugoživućih memorijskih T-limfocita tipa-1. Nemogućnost razvoja odgovarajuće memorijske imunosti u kombinaciji s istovremenim razvojem oba tipa imunosnog odgovora, mogao bi igrati veliku ulogu u patogenezi RSV-a.
Abstract (english)	RSV (respiratory syncytial virus) is the most common cause of respiratory infections in infants. Development of severe lower respiratory tract infections and frequent reinfections could relate with the simultaneous development of protective Th1 and pathogenic Th2 immune responses. Th1 is represented by predominant IFN-γ and associated with increased CXCL10 and CXCL9 production. Contrary, Th2 is represented by increased IL-4 and CCL17/CCL22 production. We have determined the chemokine profile of children with severe RSV infection, in addition to specific chemokine receptors CXCR3 and CCR4 expression on memory T cells. To confirm type-2 T-cell polarization, we also analyzed CRTh2 receptor expression. Results showed RSV specifically increases CXCL10 and CCL17 levels in acute infection, followed by inadequate immune memory development in terms of higher percentages of type-1 and type-2 TEM cells, and lower percentages of long-living type-1 memory T cells. Failure in the development of appropriate immune memory, together with the presence of both type-1 and type-2 immune response, could play an important role in RSV pathogenesis and reinfections.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:746737
Study programme	Title: Biology Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resource	Text
File origin	Born digital
Access conditions	Closed access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2017-05-16 11:29:30

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