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doctoral thesis
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The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats
Marija Skoko (2016)
University of Zagreb
Faculty of Science
Department of Biology
Cite this item:
https://urn.nsk.hr/urn:nbn:hr:217:472081
Metadata
Title
Toksičnost i oksidativni učinci pripravka ginka i antihemostatskih lijekova u štakora
Author
Marija Skoko
Mentor(s)
Domagoj Đikić
Abstract
Cilj ovog istraživanja je prikazati učinke i razlike u toksičnosti te prooksidativne i antihemostatske mehanizme triju biljnih formulacija namijenjenih ljudskoj uporabi kao dodaci prehrani, a koja sadrže pripravak biljke Ginkgo biloba, dostupne na području Republike Hrvatske. Istražen je i njihov učinak u kombinaciji s antihemostatskim lijekovima, acetilsalicilnom kiselinom i varfarinom. Istraživanje je provedeno na životinjskom modelu štakora. Testovima agregacije i koagulacije dokazano je da svi korišteni biljni pripravci produžuju vrijeme agregacije trombocita dok na koagulaciju nemaju statistički značajan učinak. Dokazano je da korištenje biljnih pripravaka u kombinaciji s lijekovima mijenja vrijednosti mjerenih biljega oksidativnog stresa, aktivnost enzima superoksid dismutaze (SOD) i katalaze te koncentraciju reduciranog glutationa (GSH) i malondialdehida (MDA) u tkivu jetre, bubrega, slezene i mozga, te u krvi. Dobiveni rezultati ukazuju na potrebu veće pozornosti prilikom upotrebe pripravka ginka i različitih antihemostatskih lijekova u svakodnevnoj kliničkoj praksi.
Keywords
ginko
platelt agregation
hemostasis
antioxidant system
warfarin
acetilsalycilic acid
Parallel title (English)
The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats
Committee Members
Nada Oršolić
(committee chairperson)
Marijana Zovko Končić
(committee member)
Petar Gaćina
(committee member)
Granter
University of Zagreb
Faculty of Science
Lower level organizational units
Department of Biology
Place
Zagreb
State
Croatia
Scientific field, discipline, subdiscipline
NATURAL SCIENCES
Biology
UDK
577
NATURAL SCIENCES
Biochemistry. Molecular biology. Biophysics
Study programme type
university
Study level
postgraduate
Study programme
Biology
Academic title abbreviation
dr.sc.
Genre
doctoral thesis
Language
Croatian
Defense date
2016
Parallel abstract (English)
The aim of this study was to demonstrate the effects and the differences in toxicity and prooxidant and antihemostatic mechanisms of three herbal dietary supplements, containing extract of Ginkgo biloba, that are available in Croatia. The goal was also to investigate their efect in combination with antihemostatic drugs, acetylsalicylic acid and warfarin. The study was conducted on animal model. Platelet aggregation and coagulation tests proved that all used herbal products prolong platelet aggregation, while on coagulation they had no statistically significant effect. It has been shown that the use of herbal dietary supplements in combination with medicaments changes the value of the measured biomarkers of oxidative stress, the activity of superoxide dismutase (SOD) and catalase and concentration of glutathione (GSH) and malondialdehyde (MDA) in tissues of liver, kidney, spleen and brain, and also in blood. The results suggested that the greater attention should be paid to the usage of these products in clinical practice.
Parallel keywords (Croatian)
ginko
agregacija trombocita
hemostaza
antioksidativni sustav
varfarin
acetilsalicilna kiselina
Version
accepted version
Resource type
text
Access condition
No public access
Note
accepted version
URN:NBN
https://urn.nsk.hr/urn:nbn:hr:217:472081
Committer
Palma Dizdarević