Toksičnost i oksidativni učinci pripravka ginka i antihemostatskih lijekova u štakora

Skoko, Marija

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doctoral thesis

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The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats

Marija Skoko (2016)

University of Zagreb
Faculty of Science
Department of Biology

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:472081

Metadata


Title	Toksičnost i oksidativni učinci pripravka ginka i antihemostatskih lijekova u štakora
Author	Marija Skoko
Mentor(s)	Domagoj Đikić
Abstract	Cilj ovog istraživanja je prikazati učinke i razlike u toksičnosti te prooksidativne i antihemostatske mehanizme triju biljnih formulacija namijenjenih ljudskoj uporabi kao dodaci prehrani, a koja sadrže pripravak biljke Ginkgo biloba, dostupne na području Republike Hrvatske. Istražen je i njihov učinak u kombinaciji s antihemostatskim lijekovima, acetilsalicilnom kiselinom i varfarinom. Istraživanje je provedeno na životinjskom modelu štakora. Testovima agregacije i koagulacije dokazano je da svi korišteni biljni pripravci produžuju vrijeme agregacije trombocita dok na koagulaciju nemaju statistički značajan učinak. Dokazano je da korištenje biljnih pripravaka u kombinaciji s lijekovima mijenja vrijednosti mjerenih biljega oksidativnog stresa, aktivnost enzima superoksid dismutaze (SOD) i katalaze te koncentraciju reduciranog glutationa (GSH) i malondialdehida (MDA) u tkivu jetre, bubrega, slezene i mozga, te u krvi. Dobiveni rezultati ukazuju na potrebu veće pozornosti prilikom upotrebe pripravka ginka i različitih antihemostatskih lijekova u svakodnevnoj kliničkoj praksi.
Keywords	ginko platelt agregation hemostasis antioxidant system warfarin acetilsalycilic acid
Parallel title (English)	The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats
Committee Members	Nada Oršolić (committee chairperson) Marijana Zovko Končić (committee member) Petar Gaćina (committee member)
Granter	University of Zagreb Faculty of Science
Lower level organizational units	Department of Biology
Place	Zagreb
State	Croatia
Scientific field, discipline, subdiscipline	NATURAL SCIENCES Biology
UDK	577 NATURAL SCIENCES Biochemistry. Molecular biology. Biophysics
Study programme type	university
Study level	postgraduate
Study programme	Biology
Academic title abbreviation	dr.sc.
Genre	doctoral thesis
Language	Croatian
Defense date	2016
Parallel abstract (English)	The aim of this study was to demonstrate the effects and the differences in toxicity and prooxidant and antihemostatic mechanisms of three herbal dietary supplements, containing extract of Ginkgo biloba, that are available in Croatia. The goal was also to investigate their efect in combination with antihemostatic drugs, acetylsalicylic acid and warfarin. The study was conducted on animal model. Platelet aggregation and coagulation tests proved that all used herbal products prolong platelet aggregation, while on coagulation they had no statistically significant effect. It has been shown that the use of herbal dietary supplements in combination with medicaments changes the value of the measured biomarkers of oxidative stress, the activity of superoxide dismutase (SOD) and catalase and concentration of glutathione (GSH) and malondialdehyde (MDA) in tissues of liver, kidney, spleen and brain, and also in blood. The results suggested that the greater attention should be paid to the usage of these products in clinical practice.
Parallel keywords (Croatian)	ginko agregacija trombocita hemostaza antioksidativni sustav varfarin acetilsalicilna kiselina
Version	accepted version
Resource type	text
Access condition	No public access
Note	accepted version
URN:NBN	https://urn.nsk.hr/urn:nbn:hr:217:472081
Committer	Palma Dizdarević