Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji

Kozić Dokmanović, Sanja

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doctoral thesis

Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2012. urn:nbn:hr:163:750911

Kozić Dokmanović, Sanja

University of Zagreb
Faculty of Pharmacy and Biochemistry

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APA 6th Edition

Kozić Dokmanović, S. (2012). Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:750911

MLA 8th Edition

Kozić Dokmanović, Sanja. "Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji." Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2012. https://urn.nsk.hr/urn:nbn:hr:163:750911

Chicago 17th Edition

Harvard

Kozić Dokmanović, S. (2012). 'Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji', Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 16 April 2024, https://urn.nsk.hr/urn:nbn:hr:163:750911

Vancouver

Kozić Dokmanović S. Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2012 [cited 2024 April 16] Available at: https://urn.nsk.hr/urn:nbn:hr:163:750911

IEEE

S. Kozić Dokmanović, "Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji", Doctoral thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:163:750911

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:750911

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Metadata

Title	Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji
Title (english)	Extra virgin olive oil and atherosclerosis biomarkers in patients on antiretroviral therapy
Author	Sanja Kozić Dokmanović MBZ: 260183
Mentor	Josip Begovac (mentor) MBZ: 143475
Mentor	Nada Vrkić (komentor)
Committee member	Jozsef Petrik (predsjednik povjerenstva)
Committee member	Renata Zrinski Topić (član povjerenstva) MBZ: 188343
Committee member	Željan Maleš (član povjerenstva)
Committee member	Josip Begovac (član povjerenstva) MBZ: 143475
Committee member	Nada Vrkić (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry Zagreb
Defense date and country	2012-02-10, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Medical Biochemistry
Universal decimal classification (UDC)	615 - Pharmacology. Therapeutics. Toxicology
Abstract	Bolesnici zaraženi HIV-om skloni su ranoj pojavi ateroskleroze zbog upale uzrokovane samim virusom, kao i zbog nuspojava antiretrovirusnog liječenja. Antiaterogeno djelovanje ekstra djevičanskog maslinovog ulja (EVOO) moglo bi umanjiti rizik od kardiovaskularnih bolesti u osoba zaraženih HIV-om. 39 HIV-om zaraženih muških ispitanika uključeno je u križni klinički pokus. Ispitanici su konzumirali EVOO i rafinirano maslinovo ulje (ROO) - placebo. Više od 50% ispitanika imalo je izražene čimbenike za aterosklerozu, a više od 90% ispitanika imalo je povećanu koncentraciju malondialdehida i povećanu katalitičku koncentraciju superoksid dismutaze. Udio rizičnih čimbenika znatno je veći u ispitanika koji se liječe inhibitorima proteaze ili abakavirom. Konzumacija ROO smanjila je koncentraciju malondialdehida za 18% u svih ispitanika, dok je konzumacija EVOO smanjila koncentracije hsCRP za 151% i brzinu sedimentacije eritrocita za 62% u ispitanika liječenih inhibitorima proteaze. Koncentracije hsCRP-a značajno su smanjene nakon konzumacije EVOO samo u ispitanika čija je suradljivost bila veća od 90%. Konzumacija maslinovih ulja nije smanjila rizik za koronarnu bolest srca i metabolički sindrom. Rizične čimbenike za kardiovaskularne bolesti potrebno je definirati i pratiti tijekom antiretrovirusnog liječenja. Učinkovitost EVOO trebalo bi potvrditi na većem broju ispitanika.
Abstract (english)	Premature atherosclerosis in HIV infected patients is associated with chronic infection by itself and side effects of antiretroviral therapy. Beneficial effect of extra virgin olive oil (EVOO) could decrease the risk for cardiovascular disease in HIV-infected patients. 39 HIV positive male participants were included in randomized crossover controlled trial. They consumed EVOO and refined olive oil (ROO) - placebo. The atherosclerosis risk factors were affected in more than 50% of participants receiving antiretroviral therapy. In more than 90% of participants malondialdehyde concentrations and superoxide dismutase cathalitic concentrations were increased. Risk factors were more affected in participants using protease inhibitors and abacavir containing antiretroviral therapy. After ROO administration, MDA concentration was 18% higher when compared to basic values. After EVOO administration, in participants using protease inhibitors containing antiretroviral therapy, erythrocyte sedimentation rate and hsCRP concentrations were 62% and 151% lower when compared to basic values, respectively. hsCRP concentrations showed a significant decrease after EVOO administration only in participants with >90% compliance. Olive oil consumption did not affect the risk for coronary heart disease and the metabolic syndrome diagnosis. Cardiovascular disease risk factors should be recognized and followed in all HIV patients receiving antiretroviral therapy. EVOO effects should be confirmed on a larger sample size.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:750911
Study programme	Title: Pharmacy and biochemistry Study programme type: university Study level: postgraduate Academic / professional title: doktor znanosti (doktor znanosti)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2016-11-16 10:19:44

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