prikaz prve stranice dokumenta Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation
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doctoral thesis
Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation
Zagreb: University of Zagreb, School of Medicine, 2019. urn:nbn:hr:105:399377
Pavlović, Nikola
University of Zagreb
School of Medicine

Cite this document

Pavlović, N. (2019). Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:399377

Pavlović, Nikola. "Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:399377

Pavlović, Nikola. "Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation." Doctoral thesis, University of Zagreb, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:105:399377

Pavlović, N. (2019). 'Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation', Doctoral thesis, University of Zagreb, School of Medicine, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:399377

Pavlović N. Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2019 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:105:399377

N. Pavlović, "Comparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:105:399377

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Metadata
TitleComparison of irrigated multi-electrode radiofrequency ablation and point-by-point ablation for pulmonary vein isolation in patients with persistent atrial fibrillation with persistent atrial fibrillation
AuthorNikola Pavlović
MentorDiana Delić Brkljačić (mentor)
MentorChristian Sticherling (komentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2019-10-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Atrial fibrillation is the most common supraventricular arrhythmia in the general population. It is related to increased morbidity and mortality and reduced quality of life. Pulmonary vein isolation has emerged and today remains the cornerstone of atrial fibrillation ablation. There are multiple different tools and technologies used to achieve pulmonary vein isolation, and irrigated multi-electrode ablation was a novel tool to perform pulmonary vein isolation. It has been evaluated in patients with paroxysmal atrial fibrillation; however there is no data on use of this technology in patients with persistent atrial fibrillation. The aim of our study was to compare irrigated multi-electrode ablation with point-by-point radiofrequency (RF) ablation in patients with persistent atrial fibrillation under-going PVI. In this prospective study, we included forty-nine patients (age 60 + 9 years, 82% male). In 24 patients, the IMEA catheter was used in conjunction with an electroanatomic mapping system. Twenty-five patients undergoing RF point-by-point ablation (RF-PVI) served as a control group. Patients were followed for 12 months with 24 Holter ECG monitoring at 3, 6, and 9 months and 7 days Holter ECG at 12 months follow up. Results have confirmed our hypothesis that procedural parameters are similar between irrigated multielectrode ablation and standard point-by-point radiofrequency ablation. Procedure time was 125 + 23 min in the IMEA group and 127 + 31 min in the RF-PVI group (P = 0.79). Fluoroscopy time was 12.2 (11 – 16.1) min with IMEA compared with 5.2 (4.1 – 9.3) min in the RF-PVI group (P, 0.001). Net ablation time was 11.8 (10.2 – 15.4) min in the IMEA group compared with 33.6 (30.3 – 40.1) min in the RF-PVI group (P, 0.001). However, cumulative ablation times were significantly longer in the IMEA group compared to RF PVI group. Although complication rates were low in our study, longer cumulative ablation times could have implications on complication rates, which needs to be verified in future studies. Success rates, defined as freedom from any atrial fibrillation at 12 months were similar between the two groups. At 12 months, 16 of 24 patients (67%) in the IMEA group compared with 17 of 25 patients (68%) in RF-PVI group were free from AF (P. 0.99). In conclusion, IMEA-PVI was associated with shorter net ablation time and longer fluoroscopy time with similar procedure duration. Irrigated multi-electrode ablation recordings were not sufficient to confirm isolation in 35% of PVs. Single procedure efficacy after 12 months was similar between the two groups.
Abstract (croatian)
Fibrilacija atrija je najučestalija supraventrikulska aritmija u općoj populaciji. Povezana je s povišenom stopom morbiditeta i mortaliteta te sniženom kvalitetom života bolesnika. Kao opcija liječenja kob dijela bolesnika, razvijena je izolacija plućnih vena koje je i danas temelj ablacijskog liječenja fibrilacije atrija. Razvijeni su brojni kateteri i tehnologije za izolaciju plućnih vena, a jedna od novijih je i multielektrodna irigacijska ablacija. Dosad postoje istraživanja koja su ispitivala učinkovitost i sigurnost navedene tehnologije kod bolesnika s paroksizmalnom fibrilacijom atrija, međutim do sada nije korištena niti ispitana kod bolesnika s perzistentnom fibrilacijom atrija. Cilj naše studije bio je usporediti novi multielektrodni irigacijski ablacijski kateter sa standardnom point-by-point radiofrekventnom ablacijom kod bolesnika s perzistentnom fibrilacijom atrija koji su podvrgnuti izolaciji plućnih vena. U studiju je uključeno 49 bolesnika (60± 9 godina, 82% muškarci). Kod 24 bolesnika PVI je učinjena multielektrodnim irigacijskim ablacijskim kateterom (IMEA-PVI) uz korištenje maping sustava, a kod 25 bolesnika radiofrekventnom ‘’point-by-point’’ ablacijom standardnim 4 mm irigacijskim kateterom (RF-PVI). Bolesnici su praćeni 24h Holter EKGom tijekom 12 mjeseci svaka tri mjeseca, a u 12-om mjesecu učinjen je 7 dnevni Holter EKG. Rezultati su pokazali da je vrijeme procedure usporedivo, ali vrijeme fluoroskopije kao i kumulativno vrijeme ablacije bili su znatno viši u IMEA grupi. Trajanje procedure bilo je 125 + 23 min u IMEA grupi i 127 + 31 min u RF-PVI grupi (P = 0.79). Vrijeme fluoroskopije bilo je 12.2 (11 – 16.1) min u IMEA grupi, a 5.2 (4.1 – 9.3) min u RF-PVI group (P = 0.001). Vrijeme ablacije kateterom bilo je 11.8 (10.2 – 15.4) min u IMEA grupi, a 33.6 (30.3 – 40.1) min u RF-PVI grupi (P= 0.001). Međutim, kumulativno vrijeme ablacije (vrijeme ablacije po RF elektrodi) bilo je značajno više u IMEA PVI grupi. I iako je incidencija komplikacija bila niska u ovom istraživanju, dulje kumulativno vrijeme ablacije bi moglo imati implikacije na incidenciju komplikacija koje su prijavljene u drugim studijama. Rezultati su potvrdili našu hipotezu da nema značajne razlike u jednogodišnjoj uspješnosti (definirana kao odsutnost fibrilacije atrija) između dvije metode.16 of 24 bolesnika (67%) u IMEA grupi i 17 od 25 pacijenata (68%) iu RF-PVI grupi nisu imali fibrilaciju atrija nakon 12 mjeseci (P=0.99). U zaključku, IMEA-PVI ablacija povezana je sa kraćom ablacijom kateterom, ali znatno duljom kumulativnom ablacijom. Također, procedura je slične duljine trajanja kao RF PVI, ali uz znatno dulje korištenje fluoroskopije. Uspješnost u održavanju sinusnog ritma nakon 12 mjeseci je jednaka u obje skupine.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:399377
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent91 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryDr Med - University of Zagreb School of Medicine Digital Repository
Created on2023-05-05 08:36:29

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