Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima

Trogrlić, Mate

prikaz prve stranice dokumenta Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima

doctoral thesis

Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima

Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:643888

Trogrlić, Mate

University of Zagreb
School of Medicine

Cite this document

APA 6th Edition

Trogrlić, M. (2017). Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:643888

MLA 8th Edition

Trogrlić, Mate. "Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima ." Doctoral thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:643888

Chicago 17th Edition

Harvard

Trogrlić, M. (2017). 'Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:643888

Vancouver

Trogrlić M. Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:105:643888

IEEE

M. Trogrlić, "Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:643888

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:643888

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Metadata

Title	Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima
Title (english)	Somatostatin receptor scintigraphy in neuroendocrine tumour patients using Technetium-99m octreotide
Author	Mate Trogrlić
Mentor	Stanko Težak (mentor)
Committee member	nije dostupno (član povjerenstva)
Granter	University of Zagreb School of Medicine Zagreb
Defense date and country	2017-11-28, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Universal decimal classification (UDC)	61 - Medical sciences
Abstract	Cilj: ove studije je bila evaluacija dodatne vrijednosti tehnecij-99m oktreotid SPECT/CT-a u odnosu na planarne scintigrame cijelog tijela (WB) i sam SPECT u detekciji i točnoj lokalizaciji lezija neuroendokrinih tumora. Metode:Ovo istraživanje je obuhvaćalo 65 bolesnika s patohistološki utvrđenom dijagnozom neurondokrinog tumora. Planarni scintigrami cijelog tijela, SPECT i SPECT/CT su snimljeni 4 sata nakon injiciranja 670MBq tehnecij-99m obilježenog oktreotida. Također su snimljeni i dodatni tomogrami (SPECT) 10 minuta po injiciranju radiofarmaka. Kliničko praćenje i praćenje konvencionalnim dijagnostičkim metodama je smatrano referentnim standardom. Rezultati: Osjetljivost SPECT/CT je iznosila 88.9%, a specifičnost 79.3%. Dijagnostička točnost planarnih scintigrama cijelog tijela iznosila je 72.3%, SPECT snimanja 73.8%, a SPECT/CT snimanja 84.6%. AUC vrijednost („area under curve“) je bila najviša za SPECT/CT (0.84), slijedilo je SPECT snimanje (0.75) te planarni scintigrami cijelog tijela (0.74). Dijagnostička točnost i AUC vrijednost su značajno bolje za SPECT/CT u odnosu na ostale ispitivane modalitete. Zaključak: Osjetljivost i dijagnostička točnost SPECT/CT u evaluaciji neuroendokrinih lezija je viša u odnosu na ostale ispitivane dijgnostičke modalitete.
Abstract (english)	Objective: The aim of this study was to evaluate the additional value of 99mTc-HYNIC-TOC SPECT/CT over planar whole-body (WB) scintigraphy and SPECT alone in the detection and accurate localisation of neuroendocrine tumour (NET) lesions. Methods: This study included 65 patients with a definitive histological diagnosis of NET prior to scintigraphy. Planar WB scintigraphy, SPECT, and SPECT/CT images were acquired at 4 h post-administration of 670 MBq 99mTc-HYNIC-TOC. Additional SPECT images at 10 min after tracer administration were also acquired. Clinical and imaging follow-up findings were considered as the reference standards. Results: The sensitivity and specificity of SPECT/CT were found to be 88.9% and 79.3%, respectively. The diagnostic accuracies of WB scintigraphy, 4h-SPECT, and SPECT/CT were 72.3, 73.8, and 84.6%, respectively. The area under curve (AUC) value for SPECT/CT (0.84) was the highest, followed by those for 4h-SPECT (0.75) and WB scintigraphy (0.74). The accuracy and AUC values of SPECT/CT were significantly better compared to those of WB scintigraphy (P < 0.001), 10 min-SPECT (P < 0.001), and 4h-SPECT (P = 0.001). Conclusion: The sensitivity and diagnostic accuracy of SPECT/CT in the evaluation of NET lesions are higher compared to those of other tested imaging modalities.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:105:643888
Study programme	Title: Biomedicine and Health Sciences Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resource	Text
Extent	95 str.
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Dr Med - University of Zagreb School of Medicine Digital Repository
Created on	2023-05-05 08:21:32

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