Breast cancer is the leading malignancy in females in the western world as well as in Croatia. In the last 20 years, the standard method of treatment disease was a complete mastectomy with lymphadenectomy of axillary lymph nodes. Modern treatment includes a conservative resection of the breast and is the standard choice at the Clinical Hospital Center Rebro where over 60% of all breast cancer operations are done with conservative methods including techniques such as quadrantectomy, and sentinel lymph node biopsy. Frequently during surgery oncoplastic techniques are used. Other than surgical treatment, mandatory adjuvant therapies such as radiotherapy, and depending on the histological features of the tumor and the extent of invasion and distant metastasis, chemotherapy and/or hormonal therapy is used. When approaching the patient, other than oncologic treatment which is the main concern for the surgeon, the disease is must be viewed from a wider perspective which includes the patient's quality of life. Quality of life depends directly on the method and outcome of treatment. Our observations and research has shown that better aesthetic results increases the patients quality of life. Quality of life is worse in patients who on the personality tests rank higher in the section for neuroticism. Neuroticism is closely associated with a higher score on the Beck depression test. Extroversion is not associated with the occurrence of depression, nor with the result of the quality of life questionnaire. From anthropometric measurements before and after surgery, we found a statistically significant association with the difference of the distance between the nipple and inframammary fold. The larger the distance, the lower quality of life. Research results suggest that based on the conducted testing and measurements, we can predict patients with an increased risk for developing symptoms of depression and reduced quality of life. Early psychological treatment and support within the hospital or psychological consultation which are offered by organisations for patients suffering from breast cancer could reduce morbidity and improve quality of life. It is also to be expected that patients who are recognized as high risk and treated earlier due to dissatisfaction of the aesthetic result would use less sick days and thus reduce the total financial cost of treatment.