Although the worldwide incidence is desreasing, gastric cancer is second cancer related cause of death . Gastric cancer is supposed to appeare through several stages of carcinogenesis and deviation of physiologic appopthosis is considered as a key moment in carconogenesis. Survivin is a member of IAP (inhibitors of apoptosis) molecular family which have generaly have a role in antiapoptotic mechanisms. Up to now, several researches concernig relationship of survivin and gastric cancer have been published, however with adversely results, both concernig the level of expression both possible relationship with clinical and pathological features of the tumor. The expression of survivin in lymph nodes has not yet been explored. Aim of this study is to determine the level of survivin expression, both in primary gastric cancer tumor, both in metastatic lymph nodes and explore the relationship between the level of expression with patohystology features of the tumor and clinical features of disease and overall survival. Results of this research have shown that there is high expression of survivin in primar and metastatic lymph node cancer and the level of expression is in correlation with poor clinicopathologic features of disease. Furthermore, we have shown that there is decreased level of expression in metastatic lymph nodes comparing to primar cancer which can suggest of possible role of survivin in changing the biology of metastatic tumor.The correlation of survivin expression with clinical features of diseases and survival has shown the signifficane of survivin as prognostic factor. The level of expression of this molecule could, on the end, become an important factor that influence the modalities of treatment and also serve as follow up marker.