Rheumatoid arthritis (RA) is an autoimmune, chronic and progressive disease characterized by synovial inflammation, damaged cartilage and bone, causing significant disability. The Routine Assessment of Patient Index Data 3 (RAPID3) is a patient-reported disease activity measure which encompasses physical function, pain, and global health in patients with rheumatoid arthritis (RA), without formal joint counts. Since hand involvement and its decreased function are hallmarks of RA, the aim of our study was to investigate the performance of RAPID3 scores with regard to hand function and quality of life. Sixty-eight consecutive patients with RA (85% female), aged 18-75 years, were included in the study and were recruited during their rheumatology outpatient visit. Apart from demographic and clinical data, the obtained parameters of interest included disease activity measurements, RAPID3, Disease activity score 28 (DAS28), assessments of the function of the hand, specifically, the Signal of functional impairment (SOFI)-hand, grip strength, and pulp-to-palm distance, as well the measure of functional ability, Health Assessment Questionnaire-Disability Index (HAQ-DI), and quality of life instrument, EUROQOL-5D-3L(EQ-5D-3L). Pearson's correlation coefficient, Student's t test and multiple regression were used in the statistical analysis of the results. The significance was set to p < 0.05. A positive correlation was found between RAPID3, scores and HAQ-DI scores, SOFI-hand scores, and pulp-to-palm distance, and negative correlation was observed between RAPID3 scores and grip strength. The positive correlation was also found between RAPID3 and EQ- 5D-3L. In addition, we have found significant correlation between EQ-5D and hand function data. This study showed that RAPID3, as a very practical tool to assess disease activity, was strongly correlated with measurements of the functional ability of the hand, and quality of life. Therefore, RAPID3 can be used as a measure of disease activity in clinical practice characterizing hand function and quality of life in patients with RA.