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doctoral thesis
Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice
Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:165020
Marinšek, Martin
University of Zagreb
School of Medicine

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Marinšek, M. (2017). Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:165020

Marinšek, Martin. "Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice ." Doctoral thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:165020

Marinšek, Martin. "Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice ." Doctoral thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:165020

Marinšek, M. (2017). 'Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:165020

Marinšek M. Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:105:165020

M. Marinšek, "Usporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:165020

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Metadata
TitleUsporedba učinaka losartana i ramiprila u liječenju akutnoga infarkta srca s elevacijom ST spojnice
Title (english)The comparison of the efficacy of ramipril and losartan in treatment of ST-elevation myocardial infarction
AuthorMartin Marinšek
VIAF: 64152138652310982921
MentorAndreja Sinkovič (mentor)
Committee membernije dostupno (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2017-12-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Polazište. Nakon akutnoga infarkta miokarda s elevacijom ST spojnice (STEMI) blokada reninangiotenzinskoga sustava (RAS) putem inhibitora angiotenzin-konvertirajućega enzima (ACE-I) ili blokatora receptora angiotenzina II (ARB) smanjuje pojavu zatajenja srca i sklonost trombozi. Između djelovanja ACE-I-ja i ARB-a postoje razlike jer više od 75 % angiotenzina II u ljudskome miokardu nastaje alternativnim putom na koji ACE-I ne utječe. Cilj. Usporedba učinka liječenja bolesnika sa STEMI-jem ramiprilom i losartanom u razdoblju od 8 tjedana i 6 mjeseci s pomoću laboratorijskih biljega, kliničkih znakova i ehokardiografskih parametara zatajenja srca. Ispitanici i metode. 108 bolesnika nakon STEMI-ja randomizano je u skupinu od 55 bolesnika liječenih ramiprilom i skupinu od 53 bolesnika liječenih losartanom i praćeni su 8 tjedana, a 55 bolesnika i za 6 mjeseci. Tijekom liječenja uspoređen je utjecaj lijekova na kliničke znakove zatajenja srca (Killip-Kimballova kategorizacija), laboratorijske biljege (NT-proBNP, PAI-1, lipidogram) i ehokardiografske parametre zatajenja srca (EFLV, LVEDD). Rezultati. Između ramiprilske i losartanske skupine bolesnika nije utvrđena statistički značajna razlika u vrijednostima laboratorijskih biljega, ehokardiografskih parametara i kliničkih znakova zatajenja srca nakon 8 tjedana i nakon 6 mjeseci liječenja. Zaključak. Nakon nekompliciranoga STEMI-ja losartan je podjednako učinkovit kao ramipril u pogledu laboratorijskih biljega, ehokardiografskih parametara i kliničkih znakova zatajenja srca.
Abstract (english)
Objectives. The use of an angiotensin-converting enzyme inhibitor (ACE-I) or an angiotensinreceptor antagonists (ARBs) reduces the incidence of heart failure and the risk of thrombosis after acute ST-elevation myocardial infarction (STEMI) blockade of the renin-angiotensinaldosterone system (RAAS).There are some differences between ACE-I and ARBs, as more than 75% of angiotensin II in human myocardium originates from the alternative pathway influenced only by ARB. Goal. To compare the effect of 8-week and 6-month treatment of AMI patients with ramipril and losartan on laboratory markers, echocardiographic parameters and clinical signs of heart failure. Patients and methods.108 patients who suffered an STEMI were randomized in a ramipril (55) and a losartan (53) group, and followed-up for 8 weeks and 6 months. During treatment the effect of drugs on clinical (Killip-Kimbal classes), laboratory markers (NT-pro BNP, PAI-1, lipidogram) and echocardiographical parameters (EFLV, LVEDD) were compared. Results. No statistically significant differences in the levels of laboratory markers, echocardiographic parameters and clinical signs of heart failure were observed between the ramipril and the losartan group, neither after 8-week nor after 6-month treatment. Conclusions. After an uncomplicated STEMI, losartan was equally effective as ramipril in terms of laboratory markers, echocardiographic parameters and clinical signs of heart failure.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:165020
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resourceText
Extent111 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryDr Med - University of Zagreb School of Medicine Digital Repository
Created on2023-05-05 08:23:34

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