Koštani fenotip miševa s transgenom za interleukin 7 (IL-7)

Žitnjak, Daniela

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doctoral thesis

Koštani fenotip miševa s transgenom za interleukin 7 (IL-7)

Zagreb: University of Zagreb, School of Medicine, 2009. urn:nbn:hr:105:269193

Žitnjak, Daniela

University of Zagreb
School of Medicine

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APA 6th Edition

Žitnjak, D. (2009). Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:269193

MLA 8th Edition

Žitnjak, Daniela. "Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) ." Doctoral thesis, University of Zagreb, School of Medicine, 2009. https://urn.nsk.hr/urn:nbn:hr:105:269193

Chicago 17th Edition

Žitnjak, Daniela. "Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) ." Doctoral thesis, University of Zagreb, School of Medicine, 2009. https://urn.nsk.hr/urn:nbn:hr:105:269193

Harvard

Žitnjak, D. (2009). 'Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) ', Doctoral thesis, University of Zagreb, School of Medicine, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:269193

Vancouver

Žitnjak D. Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2009 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:105:269193

IEEE

D. Žitnjak, "Koštani fenotip miševa s transgenom za interleukin 7 (IL-7) ", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2009. Available at: https://urn.nsk.hr/urn:nbn:hr:105:269193

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:269193

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Metadata

Title	Koštani fenotip miševa s transgenom za interleukin 7 (IL-7)
Title (english)	Bone phenotype of IL-7 transgenic mice
Author	Daniela Žitnjak MBZ: 271492
Mentor	Ana Marušić (mentor)
Committee member	nije dostupno (član povjerenstva)
Granter	University of Zagreb School of Medicine Zagreb
Defense date and country	2009-11-03, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Universal decimal classification (UDC)	61 - Medical sciences
Abstract	Miševi s transgenom za IL-7 koji je pod kontrolom Eα promotora pojačano izražavaju IL-7 u svim stanicama koje na staničnoj membrane nose MHC II antigen te razvijaju karakterističan imunološki fenotip koji obilježava porast udjela stanica pozitivnih za CD45R antigen u koštanoj srži i u perifernoj krvi. Ženke tih miševa pokazuju i koštani fenotip obilježen gubitkom trabekularne kosti u aksijalnim i dugim kostima koji se razvija tijekom njihovog starenja. Osteopenija je posljedica povećanog broja aktivnih osteoklasta na površini trabekularne kosti. Nadalje, u kulturama neadheriranih i CD45R+ stanica koštane srži transgeničnih miševa nisu uočene promjene u broju osteoblasta, unatoč povećanom osteoklastogeničnom potencijalu koštane srži. Povećani izražaj IL-7 dovodi do promjena u mikrookolišu unutar koštane srži čime su stanice preteče usmjerene prema osteoklastnoj lozi.
Abstract (english)	Mice with an interleukin (IL)-7 transgene under the control of Eα promoter overexpress IL-7 in MHC class II-positive cells and develop specific immune phenotype, marked by an increase in CD45R+ cells in both the bone marrow and peripheral blood. We show that female IL-7 transgenic mice have a bone phenotype characterized by an age-related loss of trabecular bone in both axial and long bones. Osteopenia was the result of increased number of active osteoclasts on the surface of trabecular bone. Furthermore, IL-7 transgenic mice showed increased osteoclastic but unchanged osteoblastic potential of the bone marrow in vitro, both from nonatherent bone marrow cells and CD45R+ marrow cells. IL-7 over-expression also created osteoclastogenic microenvironment within the bone marrow which promoted the commitment of precursors towards the osteoclast lineage.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:105:269193
Study programme	Title: Biomedicine and Health Sciences Study programme type: university Study level: postgraduate Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
Type of resource	Text
Extent	105 str.
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Dr Med - University of Zagreb School of Medicine Digital Repository
Created on	2023-05-05 06:50:33

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